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Determination of Diclofenac in Urine Samples by Molecularly‐Imprinted Solid‐Phase Extraction and Adsorptive Differential Pulse Voltammetry
Author(s) -
FernándezLlano Laura,
BlancoLópez M. Carmen,
LoboCastañón M. Jesús,
MirandaOrdieres Arturo J.,
TuñónBlanco Paulino
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200703895
Subject(s) - differential pulse voltammetry , molecularly imprinted polymer , solid phase extraction , extraction (chemistry) , chromatography , chemistry , silica gel , methacrylate , voltammetry , polymerization , polymer , cyclic voltammetry , selectivity , electrochemistry , electrode , organic chemistry , catalysis
A molecularly imprinted polymer for diclofenac (DCF) was prepared by thermal polymerization over silica beads using 2‐(dimethylamino)ethyl‐methacrylate as functional monomer. After silica elimination by HF treatment, the polymer was applied to the selective solid‐phase extraction of the drug from urine followed by its quantification by adsorptive differential pulse voltammetry. Results indicate that the drug could be selectively extracted from the sample and quantified at clinically relevant concentrations (μg/mL).