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A Calibration‐Base Method for the Evaluation of the Detection Limit of an Electrochemical Biosensor
Author(s) -
Lavagnini Irma,
Antiochia Riccarda,
Magno Franco
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200703847
Subject(s) - detection limit , analyte , calibration curve , biosensor , calibration , limit (mathematics) , analytical chemistry (journal) , noise (video) , biological system , chromatography , materials science , chemistry , mathematics , computer science , statistics , nanotechnology , mathematical analysis , artificial intelligence , image (mathematics) , biology
The method based on the confidence limits of a regression straight line is applied to the linear portion of the calibration curve of a biosensor in order to determine the limit of detection. A practical application gives a detection limit of an ethanol biosensor greater than that calculated by using the method of the signal‐to‐noise‐ratio, S / N =3, but the value is more reliable because it accounts for the variability in the response at analyte additions. A simple approximation of the method is also presented.