A Calibration‐Base Method for the Evaluation of the Detection Limit of an Electrochemical Biosensor | Zendy

Lavagnini Irma | Zendy; Antiochia Riccarda | Zendy; Magno Franco | Zendy

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A Calibration‐Base Method for the Evaluation of the Detection Limit of an Electrochemical Biosensor

Author(s) -

Lavagnini Irma,

Antiochia Riccarda,

Magno Franco

Publication year - 2007

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.200703847

Subject(s) - detection limit , analyte , calibration curve , biosensor , calibration , limit (mathematics) , analytical chemistry (journal) , noise (video) , biological system , chromatography , materials science , chemistry , mathematics , computer science , statistics , nanotechnology , mathematical analysis , artificial intelligence , image (mathematics) , biology

The method based on the confidence limits of a regression straight line is applied to the linear portion of the calibration curve of a biosensor in order to determine the limit of detection. A practical application gives a detection limit of an ethanol biosensor greater than that calculated by using the method of the signal‐to‐noise‐ratio, S / N =3, but the value is more reliable because it accounts for the variability in the response at analyte additions. A simple approximation of the method is also presented.

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