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Electroanalytical Determination of Lidocaine in Pharmaceutical Preparations Using Boron‐Doped Diamond Electrodes
Author(s) -
Oliveira Robson T. S.,
SalazarBanda Giancarlo R.,
Ferreira Valdir S.,
Oliveira Silvio C.,
Avaca Luis A.
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603840
Subject(s) - lidocaine , cyclic voltammetry , electrode , diamond , electrochemistry , electroanalytical method , voltammetry , active ingredient , detection limit , chemistry , chromatography , analytical chemistry (journal) , organic chemistry , pharmacology , anesthesia , medicine , potentiometric titration
A new electroanalytical procedure was developed for the determination of lidocaine in commercial local anesthetics products containing lidocaine as the active ingredient. The procedure is based on the use of electrochemical methods as cyclic and square‐wave voltammetry, with boron‐doped diamond electrodes. The oxidation of lidocaine in Britton–Robinson buffer (0.1 mol L −1 ) using this type of electrode gives rise to one irreversible peak in 1.68 V (versus Ag/AgCl). The detection and quantification limits obtained from pure water were 10.0 and 34.4 μg/L, respectively. The proposed electrochemical method was also successfully applied to the analysis of commercially available pharmaceutical preparations. The electrochemical responses of pharmaceutical preparations (gels) were identical to those of standard lidocaine. No influence of propyleneglycol present in the gels on the voltammetric responses was observed. Lidocaine recoveries ranged from 97.6% to 99.2%.