Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Whole Blood Glucose Sensor | Zendy

Bridge Kerry | Zendy; Davis Frank | Zendy; Collyer Stuart | Zendy; Higson Séamus P. J. | Zendy

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Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Whole Blood Glucose Sensor

Author(s) -

Bridge Kerry,

Davis Frank,

Collyer Stuart,

Higson Séamus P. J.

Publication year - 2007

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.200603754

Subject(s) - amperometry , membrane , glucose oxidase , electrode , materials science , biosensor , chemistry , chromatography , analytical chemistry (journal) , electrochemistry , chemical engineering , nanotechnology , biochemistry , engineering

An ultrathin composite membrane has been developed as the outer covering barrier in a model amperometric glucose oxidase enzyme electrode. The membrane was formed by cathodic electropolymerization of divinylbenzene/ethylvinylbenzene at the surface of a gold coated polyester support membrane. Permeability coefficients were determined for O 2 and glucose across membranes with a range of polymer thicknesses. Anionic interferents (such as ascorbate), were screened from the working electrode via a charge exclusion mechanism. The enzyme electrode showed an initial 10% signal drift when first exposed to whole human blood over a period of 2 hours, after which responses remained essentially stable. Whole blood patient glucose determinations yielded a correlation coefficient of r 2 =0.99 compared to standard hospital analyses.

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