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Electrochemical Redundant Microsensor Arrays for Glucose Monitoring with Patterned Polymer Films
Author(s) -
Mugweru Amos,
Clark Becky L.,
Pishko Michael V.
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603749
Subject(s) - glucose oxidase , self healing hydrogels , ethylene glycol , chronoamperometry , materials science , photoinitiator , cyclic voltammetry , biosensor , photopolymer , polymer , redox , microelectrode , chemical engineering , peg ratio , electrode , polymer chemistry , electrochemistry , chemistry , nanotechnology , polymerization , organic chemistry , monomer , composite material , engineering , metallurgy , finance , economics
Redundant microsensor arrays for glucose sensing were fabricated using photopolymerization of poly(ethylene glycol) diacrylate (PEG‐DA) with 2‐hydroxy‐2‐methyl phenyl‐propanone as photoinitiator to encapsulate the enzyme glucose oxidase. Silicon micro fabrication technologies were used to fabricate microelectrode sensor arrays on flexible polyimide sheets. These microarray sensors were individually addressable as observed using square‐wave voltammetry. Redox polymer, poly[4‐vinylpyridine Os(bipyridine) 2 Cl]‐co‐ethylamine, was first immobilized on the electrode surface and then glucose oxidase was entrapped in PEG‐DA hydrogels. The redox polymer was found to exchange electrons with glucose oxidase in biocompatible PEG‐DA hydrogels. The entrapped glucose oxidase was found to respond linearly to glucose in solution (0–20 mM) as determined using square‐wave voltammetry.