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Interaction of Bispyridinium Compounds with Phospholipid Layers in Presence and Absence of Electric Field
Author(s) -
Merrifield Jonathan,
Tattersall John,
Bird Mike,
Nelson Andrew
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603723
Subject(s) - monolayer , phospholipid , chemistry , penetration (warfare) , membrane , phosphatidylcholine , electric field , biological membrane , combinatorial chemistry , biochemistry , physics , operations research , quantum mechanics , engineering
The nonspecific biological activity of compounds with cell membranes is of great importance when considering them for pharmaceutical applications. The interactions of a group of therapeutic bispyridinium compounds with phospholipid monolayers of dioleoyl phosphatidylcholine (DOPC) on a mercury electrode (HMDE) are reported in this paper. Impedance versus frequency plots and capacitance‐potential curves were recorded for the model membrane system. The penetration of the compounds into the monolayer is shown to be dependent on the applied electric field. Both electron withdrawing and electron donating substituents of the bispyridinium compounds promote interaction with the compounds at applied negative potential.