Cobalt Phthalocyanine Molecular Electrode for the Electrochemical Investigation of the Release of Glutathione upon Copper‐Catalyzed Decomposition of  S ‐Nitrosoglutathione | Zendy

Sehlotho Nthapo | Zendy; Griveau Sophie | Zendy; Nyokong Tebello | Zendy; Bedioui Fethi | Zendy

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Cobalt Phthalocyanine Molecular Electrode for the Electrochemical Investigation of the Release of Glutathione upon Copper‐Catalyzed Decomposition of S ‐Nitrosoglutathione

Author(s) -

Sehlotho Nthapo,

Griveau Sophie,

Nyokong Tebello,

Bedioui Fethi

Publication year - 2007

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.200603656

Subject(s) - chemistry , s nitrosoglutathione , inorganic chemistry , cobalt , catalysis , pyrolytic carbon , sodium borohydride , electrochemistry , glutathione , decomposition , phthalocyanine , cobalt oxide , copper , monolayer , electrode , organic chemistry , pyrolysis , enzyme , biochemistry

Decomposition of S‐ nitrosoglutathione (GSNO) in phosphate buffer solution at physiological pH 7.4 in the presence of cuprous ion as a catalyst and sodium borohydride as a reducing agent is analyzed by observing the transient apparition of reduced glutathione GSH through its electrooxidation. Transient formation of GSH, upon decomposition of 1 mM GSNO in presence of 0.025 mM Cu(NO 3 ) 2 and 1 mM NaBH 4 was detected by using an ordinary pyrolytic graphite electrode modified with an adsorbed monolayer of cobalt phthalocyanine at 0 V vs. SCE.

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