Premium
Cobalt Phthalocyanine Molecular Electrode for the Electrochemical Investigation of the Release of Glutathione upon Copper‐Catalyzed Decomposition of S ‐Nitrosoglutathione
Author(s) -
Sehlotho Nthapo,
Griveau Sophie,
Nyokong Tebello,
Bedioui Fethi
Publication year - 2007
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603656
Subject(s) - chemistry , s nitrosoglutathione , inorganic chemistry , cobalt , catalysis , pyrolytic carbon , sodium borohydride , electrochemistry , glutathione , decomposition , phthalocyanine , cobalt oxide , copper , monolayer , electrode , organic chemistry , pyrolysis , enzyme , biochemistry
Decomposition of S‐ nitrosoglutathione (GSNO) in phosphate buffer solution at physiological pH 7.4 in the presence of cuprous ion as a catalyst and sodium borohydride as a reducing agent is analyzed by observing the transient apparition of reduced glutathione GSH through its electrooxidation. Transient formation of GSH, upon decomposition of 1 mM GSNO in presence of 0.025 mM Cu(NO 3 ) 2 and 1 mM NaBH 4 was detected by using an ordinary pyrolytic graphite electrode modified with an adsorbed monolayer of cobalt phthalocyanine at 0 V vs. SCE.