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Tagging of Model Amphetamines with Sodium 1,2‐Naphthoquinone‐4‐sulfonate: Application to the Indirect Electrochemical Detection of Amphetamines in Oral (Saliva) Fluid
Author(s) -
Goodwin Alexander,
Banks Craig E.,
Compton Richard G.
Publication year - 2006
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603596
Subject(s) - chemistry , amphetamine , sulfonate , saliva , electrochemistry , sodium , chromatography , pharmacology , organic chemistry , biochemistry , electrode , medicine , dopamine , endocrinology
Proof‐of‐concept is shown for the indirect electrochemical detection of model amphetamines, D ‐amphetamine sulfate and pseudoephedrine, based on the labeling of the amphetamine models with sodium 1,2‐naphthoquinone‐4‐sulfonate (NQS). The presence of the amphetamine models is monitored via either the reduction in the magnitude of the voltammetric peak corresponding to the electrochemical reduction of the quinone functionality of the sodium 1,2‐naphthoquinone‐4‐sulfonate or via growth of a new voltammetric peak related to reaction between the amphetamine model and NQS, both of which are well resolved from one another. The protocol is shown to be successful in artificial saliva and authentic human oral (saliva) fluid. Such a protocol may be particularly attractive for roadside testing of amphetamines in drug drivers.