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Voltammetric Behavior of Antileukemia Drug Glivec. Part I – Electrochemical Study of Glivec
Author(s) -
Diculescu Victor Constantin,
Vivan Marilene,
Brett Ana Maria Oliveira
Publication year - 2006
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603591
Subject(s) - electrochemistry , adsorption , monolayer , chemistry , electron transfer , electrode , inorganic chemistry , photochemistry , organic chemistry , biochemistry
Abstract The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH‐dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, P glivec , which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of P glivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be D O =7.35×10 −6  cm 2 s −1 in pH 4.5 0.1 M acetate buffer.

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