Voltammetric Behavior of Antileukemia Drug Glivec. Part I – Electrochemical Study of Glivec

The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH‐dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, P glivec , which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of P glivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be D O =7.35×10 −6  cm 2 s −1 in pH 4.5 0.1 M acetate buffer.