Premium
General Kinetic Model for Amperometric Sensors Based on Prussian Blue Mediator and Its Analogs: Application to Cysteine Detection
Author(s) -
Chen LinChi,
Tseng KueiSheng,
Ho KuoChuan
Publication year - 2006
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200603530
Subject(s) - prussian blue , analyte , amperometry , biosensor , chemistry , diffusion , ferrocyanide , reaction rate constant , dimensionless quantity , electrode , electron transfer , analytical chemistry (journal) , kinetics , inorganic chemistry , chromatography , electrochemistry , thermodynamics , physics , quantum mechanics , biochemistry
Prussian blue (PB) and its analogs, such as indium hexacyanoferrate (InHCF), can serve as artificial oxidases and mediate electron transfer from electrodes to analytes rapidly. Hence they are playing a growing role in the biosensor field. To gain further insight into the PB‐based amperometric sensors, a general kinetic model for the prediction of sensing current has been developed in this work. The model takes both effects of analyte diffusion and electrocatalytic reaction into consideration and defines a dimensionless system constant, θ °, in order to compare the surface catalytic rate with the analyte diffusion rate. Consequently, the mathematical expression of sensing current, I , is derived as follows: