Graphite Micropowder Modified with 4‐Amino‐2,6‐diphenylphenol Supported on Basal Plane Pyrolytic Graphite Electrodes: Micro Sensing Platforms for the Indirect Electrochemical Detection of Δ 9 ‐Tetrahydrocannabinol in Saliva | Zendy

Goodwin Alexander | Zendy; Banks Craig E. | Zendy; Compton Richard G. | Zendy

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Graphite Micropowder Modified with 4‐Amino‐2,6‐diphenylphenol Supported on Basal Plane Pyrolytic Graphite Electrodes: Micro Sensing Platforms for the Indirect Electrochemical Detection of Δ 9 ‐Tetrahydrocannabinol in Saliva

Author(s) -

Goodwin Alexander,

Banks Craig E.,

Compton Richard G.

Publication year - 2006

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.200603518

Subject(s) - pyrolytic carbon , electrochemistry , saliva , graphite , electrode , basal plane , cyclic voltammetry , tetrahydrocannabinol , highly oriented pyrolytic graphite , chemistry , materials science , chromatography , organic chemistry , cannabinoid , biochemistry , crystallography , pyrolysis , receptor

Graphite micropowder has been modified with 4‐amino‐2,6‐diphenylphenol immobilized onto a basal plane pyrolytic graphite electrode and explored for the indirect electrochemical sensing of Δ 9 ‐tetrahydrocannabinol in artificial saliva. The protocol is based on the electrochemical formation of quinoneimine which specifically reacts with Δ 9 ‐tetrahydrocannabinol resulting in the loss of the quinoneimine which can be monitored via voltammetry. It is demonstrated that Δ 9 ‐tetrahydrocannabinol can be detected in artificial saliva over the micromolar range. Such a protocol may find application in screening for drug abuse.

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