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FIA Determination of Paracetamol in Pharmaceutical Drugs by Using Gold Electrodes Modified with a 3‐Mercaptopropionic Acid Monolayer
Author(s) -
Pedrosa Valber A.,
Lowinsohn Denise,
Bertotti Mauro
Publication year - 2006
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200503483
Subject(s) - repeatability , detection limit , amperometry , monolayer , electrode , chromatography , chemistry , pharmaceutical formulation , flow injection analysis , spectrophotometry , analytical chemistry (journal) , electrochemistry , biochemistry
A flow injection analysis (FIA) method for the determination of paracetamol in pharmaceutical drugs using a gold electrode modified with a self‐assembled monolayer (SAM) of 3‐mercaptopropionic acid is described. At optimized experimental conditions the dynamic concentration range was 0.15 to 15.0 mg L −1 with a detection limit of 0.2 μg mL −1 ( S/N =3). The repeatability of current responses for injections of 10 μmol L −1 paracetamol was evaluated to be 3.2% ( n =30) and the analytical frequency was 180 h −1 . The lifetime of the modified electrode was found to be 15 days. The results obtained by using the proposed amperometric method for paracetamol determination in four different drug samples compared well with those found by spectrophotometry.