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A LiMn 2 O 4 Based Electrochemical Scheme for Selective Measurement of Dopamine
Author(s) -
Leu Hoang Jyh,
Lin Meng Shan
Publication year - 2006
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200503404
Subject(s) - ascorbic acid , chemistry , dopamine , manganese , electrochemistry , inorganic chemistry , oxidizing agent , nuclear chemistry , electrode , organic chemistry , food science , neuroscience , biology
A new cathodic scheme was developed for the determination of dopamine by flow injection analysis (FIA). A mild oxidizing agent, lithium manganese (III, IV) oxide (LiMn 2 O 4 ), as an upstream modifier can oxidize the dopamine to produce the dopaminequinone, and then the oxidized product is subsequently detected by the downstream detector at −0.1 V (vs. Ag/AgCl). In this work, the significant feature of LiMn 2 O 4 based sensing scheme possesses no interference from other tested biological amines including acetylcholine, epinephrine, glutamate, and histamine. Otherwise, there is no detectable interference from ascorbic acid, but 2% and 1% negligible interferences were found from uric acid and acetaminophen, respectively.