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Determination of Uric Acid in the Presence of Ascorbic Acid Using Poly(3,4‐ethylenedioxythiophene)‐Modified Electrodes
Author(s) -
Kumar Shanmugam Senthil,
Mathiyarasu Jayaraman,
Phani Kanala Lakshminarasimha,
Jain Yogendra Kumar,
Yegnaraman Venkatraman
Publication year - 2005
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200503375
Subject(s) - ascorbic acid , uric acid , poly(3,4 ethylenedioxythiophene) , differential pulse voltammetry , chemistry , pedot:pss , cyclic voltammetry , electrode , glassy carbon , electrochemistry , inorganic chemistry , nuclear chemistry , biochemistry , food science
A poly(3,4‐ethylenedioxythiophene) (PEDOT) modified glassy carbon electrode (GCE) was used to determine uric acid in the presence of ascorbic acid at physiological pH facilitating a peak potential separation of ascorbic acid and uric acid oxidation (ca. 365 mV), which is the largest value reported so far in the literature. Also, an analytical protocol involving differential pulse voltammetry has been developed using a microchip electrode for the determination of uric acid in the concentration range of 1 to 20 μM in presence of excess of ascorbic acid.