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Determination of Iodide and Idoxuridine at a Glutaraldehyde‐Cross‐Linked Poly‐ L ‐Lysine Modified Glassy Carbon Electrode
Author(s) -
Pereira Francisco C.,
Fogg Arnold G.,
Ugo Paolo,
Bergamo Erwing. P.,
Stradiotto Nelson.R.,
Zai Maria Valnice B.
Publication year - 2005
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200403247
Subject(s) - iodide , glutaraldehyde , electrode , chemistry , detection limit , iodine , glassy carbon , inorganic chemistry , electrochemistry , nuclear chemistry , chromatography , cyclic voltammetry , organic chemistry
The detection limit (about 0.017 μg mL −1 ) for voltammetric determination of iodide (peak at +0.87 V vs. Ag/AgCl at pH 2) at a glutaraldehyde‐cross‐linked poly‐ L ‐lysine modified glassy carbon electrode involving oxidation to iodine was found to be several orders of magnitude lower than that for the voltammetric determination on a bare glassy carbon electrode. This method was applied successfully to the determination of iodide in two medicinal formulations. Idoxuridine was determined indirectly at the same electrode by accumulating it first at −0.8 V vs. Ag/AgCl. At this potential the CI bond in the adsorbed idoxuridine is reduced giving iodide, which is then determined at the modified electrode. The method was successfully applied to the determination of idoxuridine in a urine sample.