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Highly Sensitive Electrogenerated Chemiluminescence Detecting Ranitidine Based On Chemically Modifying Microenvironment of the Chemiluminescence Reaction
Author(s) -
Zheng Xingwang,
Qu Yingjuan,
Zhang Zhujun,
Zhang Chunmei
Publication year - 2005
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200403210
Subject(s) - chemiluminescence , ranitidine , luminol , detection limit , ranitidine hydrochloride , chemistry , electrode , electrochemiluminescence , linear range , chromatography , pharmacology , medicine
Abstract Using a graphite electrode modified with vaseline and NiO, ranitidine showed a strongly ECL enhancing effect for the weak ECL signal of electrooxidation of luminol. Based on this finding, a more sensitive ECL method for ranitidine was firstly proposed. Under the optimum experimental conditions, the ranitidine hydrochloride concentration in the range of 3.0×10 −8 –9.0×10 −6 mol/L was proportional to the enhancing ECL signal and offered a 9×10 −9 mol/L detection limit for ranitidine hydrochloride. At the same time, based on the investigation on this ECL reaction mechanism, a new concept, to improve the suitable ECL reaction micro‐environment with chemically modified electrode technique for the better analytical performances of ECL analysis was also firstly proposed.