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Enhanced Oxidation of Simvastatin at a Multi‐Walled Carbon Nanotubes‐Dihexadecyl Hydrogen Phosphate Composite Modified Glassy Carbon Electrode and the Application in Determining Simvastatin in Pharmaceutical Dosage Forms
Author(s) -
Zhang Huajie,
Hu Chengguo,
Wu Shujuan,
Hu Shengshui
Publication year - 2005
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200403137
Subject(s) - carbon nanotube , electrode , electrochemistry , detection limit , composite number , simvastatin , materials science , glassy carbon , graphite , chemical engineering , nuclear chemistry , inorganic chemistry , chemistry , nanotechnology , cyclic voltammetry , chromatography , composite material , medicine , engineering
A sensitive electrochemical method for the determination of simvastatin (SV) was established, based on the enhanced oxidation of SV at a multi‐walled carbon nanotubes‐dihexadecyl hydrogen phosphate composite modified glassy carbon electrode (MWNTs‐DHP/GCE). The voltammetric studies showed that MWNTs instead of DHP or GCE could effectively catalyze the oxidation of SV. The dependence of oxidation current on SV concentration was explored under optimal conditions, which exhibited a good linear relationship in the range of 1.0×10 −7 –7.5×10 −6 M. The detection limit of SV was also examined and a low value of 5.0×10 −8 M was obtained for 5 min accumulation ( σ =3). This electrode was applied to the detection of SV in drug forms and the results were in accordance with those obtained by UV spectroscopy.