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Electrochemistry of Nucleic Acids at Solid Electrodes and Its Applications
Author(s) -
delosSantosÁlvarez Patricia,
LoboCastañón M. Jesús,
MirandaOrdieres Arturo J.,
TuñónBlanco Paulino
Publication year - 2004
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200402995
Subject(s) - nucleic acid , electrochemistry , redox , electrode , biosensor , dna , nanotechnology , combinatorial chemistry , chemistry , molecule , materials science , inorganic chemistry , organic chemistry , biochemistry
The knowledge of the redox chemistry of nucleic acids (NA) is of paramount importance in cancer and aging research. Charge migration through DNA is also involved in biologically relevant functions such as DNA damage and repair. In the first part of this article the main aspects of the electrochemistry of nucleic acids at solid electrodes are revised, including redox processes, photoelectroactivity and electrical conductivity. In the second part, an overview of its applications is presented. Methods for electrochemical detection of NA, NA‐based biosensors for detection of nonnucleic acid molecules, studies on the nature and dynamics of interactions and structural conformations of NA, are some applications that take advantage of NA electrochemistry at solid electrodes.