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The Voltammetric Behavior of Superoxide Dismutase/Catalase Mimics
Author(s) -
O'Hare Danny,
Fucassi Flavia,
Cragg Peter J.,
Green Michael H. L.
Publication year - 2003
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200390133
Subject(s) - chemistry , ethylenediamine , superoxide , superoxide dismutase , cyclic voltammetry , catalase , inorganic chemistry , acetonitrile , chloride , voltammetry , nuclear chemistry , medicinal chemistry , electrochemistry , enzyme , organic chemistry , electrode
Abstract The voltammetric behavior of the superoxide dismutase/catalase mimics [( N,N′ ‐bis(salicylidene)ethylenediamine)Mn(III)]Cl (or salenMn(III) chloride) 1 and [( N,N′ ‐bis(3‐methoxysalicylidene)ethylenediamine)Mn(III)]Cl (or 3,3′‐methoxysalenMn(III) chloride) 2 in acetonitrile is described. Both compounds show quasi‐reversible one‐electron reductions to the Mn(II) compound. Electroanalytical techniques are used to follow the reaction between superoxide and 1 and 2 and it is shown that it is the reduced Mn(II) compounds which scavenge superoxide. It is also shown that both compounds electrocatalytically generate superoxide in the presence of dissolved dioxygen. The rate constant for this reaction was determined for both compounds using microelectrode steady state voltammetry. A general reaction scheme for interactions between these compounds and both dissolved dioxygen and superoxide is proposed.