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NADH Oxidation Using Carbonaceous Electrodes Modified with Dibenzo‐Dithia‐Diazapentacene
Author(s) -
Munteanu FlorentinaDaniela,
Dicu Delia,
Popescu Ionel Catalin,
Gorton Lo
Publication year - 2003
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200390044
Subject(s) - redox , chemistry , electrochemistry , adsorption , inorganic chemistry , cyclic voltammetry , graphite , phenothiazine , glassy carbon , nuclear chemistry , voltammetry , electrode , organic chemistry , medicine , pharmacology
The electrochemical and the electrocatalytic behavior for NADH oxidation of a newly synthesized phenothiazine derivative, 16 H ,18 H ‐dibenzo[c,1]‐7,9‐dithia‐16,18‐diazapentacene (DDDP), adsorbed on solid spectrographic graphite and on graphite powder or on zirconium phosphate (ZP), both entrapped in carbon paste, were compared. Experiments using cyclic voltammetry and a rotating disk electrode, performed in different experimental conditions (various pH values and NADH concentrations), showed that i) in the pH range between 4 and 8, the E °' value for DDDP adsorbed on ZP becomes pH independent; ii) in contrast to other redox mediators, adsorption of DDDP on ZP induced a significant negative shift of the E °' value; iii) the reaction rate for electrocatalytic oxidation of NADH is markedly increased by adsorbing the mediator on ZP, being further improved by the presence of Ca 2+ ions in the solution.