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Voltammetric Oxidation of Ambroxol and Application to Its Determination in Pharmaceuticals and in Drug Dissolution Studies
Author(s) -
Demircigil B. Tolga,
Uslu Bengi,
Özkan Yalçin,
Özkan Sibel A.,
Sentürk Zühre
Publication year - 2003
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200390029
Subject(s) - dissolution , ambroxol , differential pulse voltammetry , chemistry , electrochemistry , aqueous solution , voltammetry , dissolution testing , drug , glassy carbon , cyclic voltammetry , electrode , organic chemistry , pharmacology , biopharmaceutics classification system , medicine , anesthesia
Abstract A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8–11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.