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Selective Voltammetric Detection of Uric Acid in the Presence of Ascorbic Acid at Well‐Aligned Carbon Nanotube Electrode
Author(s) -
Ye JianShan,
Wen Ying,
De Zhang Wei,
Gan Leong Ming,
Xu Guo Qin,
Sheu FwuShan
Publication year - 2003
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200302752
Subject(s) - ascorbic acid , differential pulse voltammetry , detection limit , cyclic voltammetry , carbon nanotube , electrode , electrochemistry , chemistry , nanotube , voltammetry , analytical chemistry (journal) , inorganic chemistry , nuclear chemistry , materials science , chromatography , nanotechnology , food science
The voltammetric behaviors of uric acid (UA) and L ‐ascorbic acid ( L ‐AA) were studied at well‐aligned carbon nanotube electrode. Compared to glassy carbon, carbon nanotube electrode catalyzes oxidation of UA and L ‐AA, reducing the overpotentials by about 0.028 V and 0.416 V, respectively. Based on its differential catalytic function toward the oxidation of UA and L ‐AA, the carbon nanotube electrode resolved the overlapping voltammetric response of UA and L ‐AA into two well‐defined voltammetric peaks in applying both cyclic voltammetry (CV) and differential pulse voltammetry (DPV), which can be used for a selective determination of UA in the presence of L ‐AA. The peak current obtained from DPV was linearly dependent on the UA concentration in the range of 0.2 μM to 80 μM with a correlation coefficient of 0.997. The detection limit (3 δ ) for UA was found to be 0.1 μM. Finally, the carbon nanotube electrode was successfully demonstrated as a electrochemical sensor to the determination of UA in human urine samples by simple dilution without further pretreatment.