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Electrochemical Oxidation of 8‐Oxo‐2′‐Deoxyguanosine on Glassy Carbon, Gold, Platinum and Tin(IV) Oxide Electrodes
Author(s) -
Langmaier Jan,
Samec Zdeněk,
Samcová Eva
Publication year - 2003
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200302732
Subject(s) - cyclic voltammetry , platinum , glassy carbon , electrochemistry , electrode , chemistry , tin oxide , inorganic chemistry , amperometry , electron transfer , oxide , photochemistry , organic chemistry , catalysis
Cyclic voltammetry was used to investigate the oxidation of 8‐oxo‐2′‐deoxyguanosine (8‐oxo‐dG) on the glassy carbon (GC), platinum, gold and SnO 2 electrodes over a range of the sweep rate, 8‐oxo‐dG concentration and the solution pH. Reaction mechanism that is common to all these electrodes involves the two‐electron two‐proton charge transfer step followed by the irreversible chemical reaction(s). Rate of the charge transfer reaction decreases with the increasing solution pH (GC, Pt, Au), and depends on the nature of the electrode material following the sequence GC>Pt, Au>>SnO 2 . These effects can be related to the degree of oxidation of the electrode surface (Pt, Au, SnO 2 ), or to the density of the active surface sites (GC). Any of these electrodes can be used for the fabrication of an amperometric detector for 8‐oxo‐dG .