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Differential pulse adsorptive anodic stripping voltammetric determination of pipemidic acid in tablets at a carbon fiber microdisk electrode
Author(s) -
He YaNan,
Chen HongYuan
Publication year - 1997
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140091810
Subject(s) - stripping (fiber) , anodic stripping voltammetry , electrode , adsorptive stripping voltammetry , anode , chemistry , buffer solution , pulse (music) , analytical chemistry (journal) , phosphate buffered saline , voltammetry , detection limit , carbon paste electrode , materials science , chromatography , electrochemistry , cyclic voltammetry , optics , composite material , physics , detector
An adsorptive anodic stripping voltammetric determination of pipemidic acid (PPA) in tablets with a carbon fiber microdisk electrode is presented. A sensitive differential pulse adsorptive anodic stripping peak of PPA was found at 1.06 V (vs. Ag/AgCl) in pH 7.0 phosphate buffer solutions. Under the optimal conditions (buffer solution: pH 7.0 0.20 mol/L PBS, accumulation time: 30s, accumulation potential: 0.10V, pulse height: 80 mV, pulse width: 80ms) the height of the peak linearly increased with the concentration of PPA in the range of 2.8 × 10 −7 –1.2 × 10 −6 mol/L. The method is not affected by oxygen, no extraction was required before the voltammetric analysis, and the excipients present in the PPA tablets show no interference with the analysis. The method was used for the determination of PPA in tablets with satisfactory results.