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Electrochemical detection of disodium 3,3′‐azobis‐(6‐hydroxy‐) benzoate (olsalazine sodium)
Author(s) -
Eriksson Alf,
Nyholm Leif
Publication year - 1997
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140091615
Subject(s) - detection limit , electrochemistry , sodium benzoate , chemistry , sodium , aqueous solution , solubility , chromatography , nuclear chemistry , organic chemistry , electrode , food science
Electrochemical detection of disodium 3,3′‐azobis‐(6‐hydroxy‐)benzoate, olsalazine sodium, in reversed phase liquid chromatography is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determination of the solubility of olsalazine sodium in aqueous solutions. The solubility was found to be 2 × 10 −8 M and 4 × 10 −6 M at pH 1.0 and 3.5, respectively.