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Critical comparison of metallized and mediator‐based carbon paste glucose biosensors
Author(s) -
Wang Joseph,
Chen Liang,
Liu Jie
Publication year - 1997
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140090407
Subject(s) - biosensor , ascorbic acid , amperometry , glucose oxidase , electrode , ferrocene , selectivity , detection limit , materials science , mediator , rhodium , carbon fibers , catalysis , inorganic chemistry , combinatorial chemistry , chemistry , nanotechnology , electrochemistry , chromatography , organic chemistry , composite material , medicine , food science , composite number
The performance of metallized carbon oxidase‐based biosensors is critically compared with that of mediator‐based enzyme electrodes. Dimethyl ferrocene and rhodium metal centers are used as model mediator and catalyst, respectively, in connection to carbon‐paste electrode transducers and assays of glucose. The rhodium‐containing bioelectrode displays enhanced selectivity (particularly improved discrimination against ascorbic acid), lower sensitivity, faster response time, greater oxygen dependence, and similar detection limit in comparison to the mediated electrode. In addition to assessing the relative merits of both strategies, the data offer useful insights into the behavior of these ‘first’‐ and ‘second‐generation’ oxidase amperometric electrodes.