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Electrochemical biosensors for inhibitor determination: Selectivity and sensitivity control
Author(s) -
Budnikov Herman C.,
Evtugyn Gennady A.
Publication year - 1996
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140080821
Subject(s) - biosensor , potentiometric titration , membrane , amperometry , chemistry , selectivity , nitrate , cellulose , electrochemistry , chromatography , gelatin , electrode , organic chemistry , biochemistry , catalysis
Abstract The behavior of cholinesterase based potentiometric and amperometric biosensors with renewable membranes toward irreversible inhibitor determination has been investigated. Tracing paper, gelatin and cellulose nitrate were examined, as membrane materials. The membranes are replaced in the biosensor assembly after 15–20 inhibition measurements. The detection limits as well as other analytical characteristics of inhibitor determination for different enzyme supports and detection systems are compared and discussed.