A potentiometric polypyrrole‐based glucose biosensor | Zendy

Trojanowicz Marek | Zendy; Hitchman Michael L. | Zendy

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A potentiometric polypyrrole‐based glucose biosensor

Author(s) -

Trojanowicz Marek,

Hitchman Michael L.

Publication year - 1996

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.1140080311

Subject(s) - polypyrrole , glucose oxidase , biosensor , potentiometric titration , amperometry , potentiometric sensor , electrode , chemistry , platinum , linear range , inert , polymer , conductive polymer , materials science , analytical chemistry (journal) , chromatography , electrochemistry , nanotechnology , detection limit , organic chemistry , catalysis

A new concept is described for monitoring a biomolecule with a sensor having an enzyme entrapped in a conducting polymer. This is based on the sensitivity of the electroactive polymer itself to changes of pH in solution. The concept has been investigated for a glucose sensor with glucose oxidase (GOD) immobilized in a polypyrrole (PPy) layer on an inert platinum electrode. Measurements with a Pt/PPy/GOD electrode for glucose concentrations in the physiological range gave a linear correlation with logarithm of concentration over one decade with a satisfactory dynamic response. There was practically no change of slope or range of linear response to glucose after several days of use; this was in contrast to the amperometric response of the detector when there was about a 50% loss of sensitivity.

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