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Optimization by experimental design of the adsorptive stripping voltammetric parameters in the determination of cinoxacin
Author(s) -
Gratteri Paola,
Furlanetto Sandra,
Pinzauti Sergio,
Leardi Riccardo,
Corti Piero
Publication year - 1995
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140071212
Subject(s) - adsorptive stripping voltammetry , chemistry , hanging mercury drop electrode , chromatography , stripping (fiber) , differential pulse voltammetry , analytical chemistry (journal) , calibration curve , electrode , adsorption , voltammetry , materials science , detection limit , electrochemistry , cyclic voltammetry , composite material , organic chemistry
The quinolone antibacterial agent cinoxacin was studied by adsorptive stripping voltammetry making use of its controlled interfacial accumulation on a static mercury drop electrode. Measurements were obtained in differential pulse mode and optimized by experimental design. The chemometric approach allowed the identification of a strong interaction between pH and pulse amplitude. The dynamic linear range of calibration was extended from 0.4 to 9 × 10 −8 M. Analyses of cinoxacin capsules and spiked human urine sample were carried out without the need of previous extraction or filtration. A cleanup procedure was required to separate cinoxacin from the human plasma matrix prior to adsorptive stripping analysis.