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Electroanalytical and biocompatibility studies on microfabricated array sensors
Author(s) -
Lindner Ernô,
Cosofret Vasile V.,
Buck Richard P.,
Johnson Timothy A.,
Ash R. Bruce,
Neuman Michael R.,
Kao Weiyuan J.,
Anderson James M.
Publication year - 1995
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140070913
Subject(s) - plasticizer , membrane , valinomycin , biocompatibility , polyvinyl chloride , chemistry , potassium , nuclear chemistry , chemical engineering , polymer chemistry , materials science , organic chemistry , biochemistry , engineering
pH, potassium and calcium ion‐selective membranes based on neutral ionophores TDDA, valinomycin and ETH‐1001, respectively and immobilized in high molecular weight (HMW) and carboxylated poly(viny1 chloride) (PVC‐COOH) as well as in aliphatic polyurethane (Tecoflex) matrices with normal and reduced amounts of plasticizers were investigated with respect of their general analytical properties, biocompatibility and cellular responses. The analytical performance of the PVC‐COOH based potassium electrodes was not effected by reducing the plasticizer content from 66% (w/w) to 33% (w/w) while that of pH electrodes was significantly deteriorated at the lower plasticizer level. High molecular weight PVC and Tecoflex membranes with low plasticizer content induce less inflammatory response compared to membranes cast with high plasticizer concentrations or PVC‐COOH as matrix. o ‐NPOE plasticized membranes are correlated with an increased acute, but a decireased chronic inflammatory response, when compared to membranes cast with DOS as plasticizer.