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Microfabrication technology of flexible membrane based sensors for in vivo applications
Author(s) -
Buck Richard P.,
Cosofret Vasile V.,
Lindner Erno,
Ufer Stefan,
Mudaras Marcel B.,
Johnson Timothy A.,
Ash R. Bruce,
Neumun Michael R.
Publication year - 1995
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140070910
Subject(s) - microfabrication , microelectrode , microelectronics , materials science , electrode , potentiometric titration , substrate (aquarium) , biomedical engineering , multielectrode array , membrane , biosensor , nanotechnology , planar , optoelectronics , chemistry , computer science , medicine , fabrication , biochemistry , alternative medicine , oceanography , pathology , geology , computer graphics (images)
Potentiometric ion‐sensitive planar microelectrode arrays, and amperornetric enzyme‐containing biosensors were fabricated by photolithographic microelectronic technology on a flexible polyimide substrate. The steps of the microelectronics processing are summarized in more detail than previously described. The ion‐selective electrodes were tested in blood serum, whole blood, and in the hamstring muscle of anesthetized rabbits. The test and performance characteristics of planar pH are emphasized, and K + , Na + , and Ca 2+ data are included in this review. New applied results are presented from experiments where the electrodes have been implanted into an in situ porcine beating heart at the midmyocardial depth in order to monitor H + and K + changes during the course of coronary artery occlusion.