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Electrochemical oxidation of DNA at a gold microelectrode
Author(s) -
Pang DaiWen,
Qi YiPeng,
Wang ZongLi,
Cheng JieKe,
Wang JiaWang
Publication year - 1995
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140070817
Subject(s) - electrochemistry , cyclic voltammetry , electrode , dna , microelectrode , adsorption , chemistry , voltammetry , inorganic chemistry , organic chemistry , biochemistry
The electrochemical oxidation of DNA at a gold microelectrode has been investigated using cyclic voltammetry with a homemade microliter cell. Denatured DNA is adsorbed and oxidized more easily at the gold electrode than native DNA. The electrochemical oxidation of DNA also depends on its strand length. The DNA oxidation product adsorbs strongly on the gold electrode, so poisoning and inactivating its surface; the adsorbed product also inhibits electrooxidation of the gold surface.