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Simultaneous determination of copper, lead, cadmium, and zinc in previously lyophilized biological tissues using flow‐injection analysis/anodic stripping voltammetry
Author(s) -
Izquierdo A,
de Castro M. D. Luque,
Valcárcel M.
Publication year - 1994
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140061015
Subject(s) - anodic stripping voltammetry , certified reference materials , cadmium , zinc , flow injection analysis , copper , analyte , chemistry , detection limit , stripping (fiber) , chromatography , voltammetry , materials science , electrode , electrochemistry , organic chemistry , composite material
Improvements in three main aspects of the analysis of metal traces in biological tissues are proposed, namely: (a) lyophilization of the samples both to preserve them and to favor the digestion process; (b) digestion of the lyophilized tissues using an effective and fast procedure; and (c) automatic determination of the target analytes by flow‐injection analysis/anodic stripping voltammetry (FIA/ASV). After optimization of these steps, the overall procedure was successfully applied to the simultaneous determination of copper, lead, cadmium, and zinc in certified reference materials (CRMs) and fresh bovine liver samples with good results. Finally, the performance of the method was validated by a statistical study using parameters of the certification campaign of the CRMs; the results obtained being within, or close to, the confidence levels of the certification campaign.