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Differential pulse polarographic determination of omeprazole in pharmaceutical preparations
Author(s) -
Özaltin Nuran,
Temizer Aytekin
Publication year - 1994
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140060915
Subject(s) - polarography , omeprazole , supporting electrolyte , pulse (music) , chemistry , electrolyte , analytical chemistry (journal) , peak current , buffer solution , chromatography , electrode , electrochemistry , voltage , inorganic chemistry , pharmacology , medicine , physics , quantum mechanics
A new electroanalytical method was developed for the analysis of omeprazole. Various polarographic techniques and supporting electrolytes were examined. Best results were obtained with differential pulse polarography (DPP) in borate buffer (pH 9.0) solution. Linear response was observed from 2.0 × 10 −7 M to 2.0 × 10 −5 M. The peak potential was observed at –1.28 V (vs. Ag/AgCl). The developed method was applied to two different commercial hard gelatin capsules, containing enteric‐coated granules, preparations. The relative standard deviations were found to be 3.04% (brand A) and 2.88% (brand B).