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The polarographic behavior of the antitumor agent tauromustine and assay of its tablets
Author(s) -
Belal F.
Publication year - 1993
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140050713
Subject(s) - polarography , dropping mercury electrode , limiting current , chemistry , limiting , diffusion , electrode , diffusion current , adsorption , analytical chemistry (journal) , direct current , chromatography , electrochemistry , current (fluid) , inorganic chemistry , thermodynamics , physics , mechanical engineering , power (physics) , engineering
Tauromustine was found to be reducible at the dropping mercury electrode (DME) over the whole pH range in Britton‐Robinson (BR) buffers. A well‐defined cathodic wave was produced in the acid range, followed by an ill‐defined, more negative additional wave starting from pH 4.0. The main reduction wave was characterized as being diffusion‐controlled, although adsorption phenomena played a limited role in the electrode process. Using either direct current or differential pulse polarographic modes, the limiting current‐concentration plot is linear over a convenient range with a minimum detectability of 5 × 10 −8 M using the latter technique. Tablets containing tauromustine (20 and 50 mg) were successfully analyzed adopting the United States Pharmacopoeia (USP) content uniformity test.