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Enhanced amperometric detector for local anesthetics in liquid chromatography with metal‐oxide dispersed glassy carbon electrodes
Author(s) -
Zhou Jianxun,
Zhang Lijing,
Wang Erkang
Publication year - 1993
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140050406
Subject(s) - amperometry , electrode , glassy carbon , oxide , metal , selectivity , materials science , chromatography , chemistry , analytical chemistry (journal) , inorganic chemistry , electrochemistry , cyclic voltammetry , organic chemistry , catalysis
Chemically modified electrodes (CMEs) prepared by the dispersion of metal oxide particles on a glassy carbon (GC) substrate greatly enhance the voltammetric response and amperometric detection of local anesthetics following liquid chromatography (LC). The enhancement is more pronounced with the GC electrodes dispersed by the metal oxides of higher oxidation states (+3, +4) and for the species exhibiting relatively slow electrode kinetics under given conditions. With an applied potential of 1.2 V (vs. SCE), LC amperometric detection of the analytes at the α‐alumina modified GC surface gives detection limits 2–5 times lower than those obtained at the bare electrode. The metal oxide‐dispersed electrodes display significant improvement in sensitivity, and selectivity and indicate excellent preparation reproducibility and performance stability.