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Electrochemical analysis of arsenic compounds for veterinary use by two polarographic methods
Author(s) -
Tzedakis T.,
Comtat M.
Publication year - 1992
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140041007
Subject(s) - polarography , chemistry , electrochemistry , arsenic , resolution (logic) , combinatorial chemistry , chromatography , electrode , inorganic chemistry , organic chemistry , computer science , artificial intelligence
Some compounds with the general formula(I) have an antiparasitic effect on animals and are used against heart disease induced by trypanosomes. A rapid, precise and selective analysis of species (I) and RNHC 6 H 4 AsO 3 H 2 (II), RNHC 6 H 4 As O (III), and R'SH (IV), appearing as intermediates, is necessary in order to regulate the synthesis processes if (I) and (II), to identify and measure the products before using them in the reactor, and to control their purity before scaling up. Tast polarography and differential pulse polarography convert quickly the concentration of these compounds into current intensity suitable for control of the process. The first method makes the assay in oxidation of (IV) possible, but the resolution is insufficient to obtain the species (III) and (I). The assay, in reduction of (II) is possible, but with interferences of (III). The second method, on the other hand, using oxidation of (I) in a basic medium provides sufficient resolution to analyze (I) and (III) with a precision on the order of 5%.