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Dissociation constants of sore anti‐inflammatory agents (α‐phenylpropionic acids) in lsopropyl and tert ‐butyl alcohol media
Author(s) -
Bosch Elisabeth,
Rodés Carles,
Rosés Martí
Publication year - 1991
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140030420
Subject(s) - isopropyl alcohol , titration , dissociation constant , chemistry , alcohol , isopropyl , dissociation (chemistry) , organic chemistry , inorganic chemistry , biochemistry , receptor
The p K a of several α‐phenylcarboxilic anti‐inflammatory drugs in both isopropyl and tert ‐butyl alcohols have been determined by means of potentiometry. The dissociation constant values of their tetrabutylammonium salts, which are necessary for computation of the acidity constants, have been determined conductometrically. The results show that both the drug acid strength resolution and the pH break in titration curves are greater in tert ‐butyl than in isopropyl alcohol, but both alcohols can be used in everyday titrations. Titrations in one commercial pharmaceutical preparation have been carried out successfully.