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Polarographic and voltammetric determination of sodium and tetramethylammonium mercaptoundecahydro‐ closo ‐dodecaborates
Author(s) -
Jelen F.,
Paleček E.,
Štrouf O.
Publication year - 1991
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140030205
Subject(s) - tetramethylammonium , polarography , dropping mercury electrode , chemistry , detection limit , mercury (programming language) , voltammetry , inorganic chemistry , electrode , sodium , differential pulse voltammetry , analytical chemistry (journal) , nuclear chemistry , electrochemistry , chromatography , cyclic voltammetry , ion , organic chemistry , computer science , programming language
Sodium and tetramethylammonium mercaptoundecahydro‐ closo ‐dodecaborates (used in cancer therapy) produce sparingly soluble compounds with a mercury electrode. These compounds can be determined using differential pulse polarography at the dropping mercury electrode in the concentration range 1.5 × 10 −5 to 5 × 10 −7 M. Detection limit below 5 × 10 −9 M can be attained with stripping voltammetry with relatively short accumulation times. Effects of various conditions are explored. The techniques are suitable for the analysis of pharmaceutical preparations containing mercaptoborate‐S.