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Electroanalytical study of the hydrolysis of the thienodiazepine clotiazepam
Author(s) -
Higelmo Fátima,
Alonso Rosa M.,
Jiménez Rosa M.
Publication year - 1991
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140030112
Subject(s) - polarography , chemistry , hydrolysis , hydroxide , reaction rate constant , alkaline hydrolysis , inorganic chemistry , arrhenius equation , analytical chemistry (journal) , pulse (music) , kinetics , activation energy , chromatography , organic chemistry , voltage , physics , quantum mechanics
The hydrolysis reaction in an alkaline medium of the thiendodiazepine Clotiazepam has been studied by differential pulse polarography at various pH values at 25, 37, and 50°C. In an alkaline medium, Clotiazepam exhibits two well‐defined polarographic peaks, attributed to the azomethine group of the parent compound and the carboxylic group of the hydrolysis product, with a potential difference of 0.160 V, practically constant in the pH range studied. Kinetic studies of the reversible hydrolysis process based on the current changes with time of the first polarographic peak in indicate that the process is a pseudo‐first‐order reaction with a rate constant dependent on hydroxide ion concentration. Arrhenius parameters were also calculated. A voltammetric study of the hydrolysis product has been carried out, and determination methods have been developed by differential pulse voltammetry and differential pulse polarography.