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Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode
Author(s) -
Goyal R. N.,
Kumar Anoop
Publication year - 1990
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140020707
Subject(s) - pyrolytic carbon , electrochemistry , electrode , graphite , trimethoprim , chemistry , inorganic chemistry , oxidation process , chemical engineering , organic chemistry , biochemistry , pyrolysis , engineering , antibiotics
The electrochemical oxidation behavior of trimethoprim has been investigated at a pyrolytic graphite electrode over a wide pH range (1.35–10.71). Below pH 3.2, trimethoprim is electrooxidized in two well‐defined steps, each involving 4e, 4H + . Only one well‐defined oxidation peak was observed above pH 3.5 however. Products corresponding to each peak have been separated and characterized by thin‐layer chromatography (TLC), infra red (IR), and mass spectra. A tentative mechanism associated with the voltammetric oxidation has been proposed to account for the observed experimental behavior. The same product has also been observed during the metabolic oxidation of trimethoprim in albino rats.