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Electrochemical oxidation of dacarbazine and its major metabolite (AIC) on carbon electrodes
Author(s) -
Rodriguez José R. Barreíra,
Garcia Agustin Costa,
Ordieres Arturo J. Miranda,
Blanco Paulino Tuñón
Publication year - 1989
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140010609
Subject(s) - differential pulse voltammetry , electrochemistry , chemistry , dacarbazine , linear sweep voltammetry , yield (engineering) , cyclic voltammetry , voltammetry , metabolite , carbon fibers , electrode , nuclear chemistry , materials science , biochemistry , metallurgy , melanoma , biology , genetics , composite material , composite number
The electrochemical behavior of the antitumor agent dacarbazine (DTIC) and its major metabolite, 5‐aminoimidazole‐4‐carboxamide (AIC), on carbon paste electrodes has been studied. Linear sweep voltammetry (LSV) and differential pulse voltammetry (DPV) have been applied, showing that both molecules are active in oxidation. Both compounds are oxidized in a two‐electron process, presenting a charge transfer coefficients (β) of 0.44 ± 0.03 and 0.48 ± 0.03 for DTIC and AIC, respectively, which indicate slow processes. The oxidation mechanisms proposed for each of these compounds seem to yield the same final product, the 5‐hydroxyimidazol‐4‐carboxamide. DPV proved to be a valuable analytical technique that is suitable for distinguishing and analyzing both compounds when the most adequate medium (0.1 M HCIO 4 ) and operating conditions are chosen.