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Electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole at a glassy carbon electrode
Author(s) -
Carrazon J. M. Pingarron,
Recio A. Dominguez,
Diez L. M. Polo
Publication year - 1989
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.1140010406
Subject(s) - differential pulse voltammetry , electrode , electroanalytical method , voltammetry , glassy carbon , analytical chemistry (journal) , diffusion , cyclic voltammetry , limiting , carbon fibers , electrochemistry , chemistry , materials science , chromatography , potentiometric titration , thermodynamics , composite material , physics , composite number , mechanical engineering , engineering
An electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole oxidation processes at a glassy carbon electrode using different voltammetric techniques was carried out. Results obtained at a rotating disk electrode allow the determination of the pK a values of the reduced and oxidized forms. Limiting currents are diffusion controlled in concentration ranges of 1.0 × 10 −5 to 5.0 × 10 −5 and 2.0 × 10 −5 to 6.0 × 10 −5 mol L −1 for Succinylsulfathiazole and phtalylsulfathiazole, respectively. Adsorption phenomena occur at higher concentrations, becoming stronger as the acidity of the medium increases. From differential pulse voltammetry at a stationary electrode, the limits of determination were 3.7 × 10 −6 and 4.7 × 10 −6 mol L −1 for succinylsulfathiazole and phtalylsulfathiazole, respectively. Interferences between the two sulfa drugs were studied. The application of differential pulse voltammetry at a stationary electrode gave good results for the determination of phtalylsulfathiazole in a commercial pharmaceutical preparation.