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Lean mass predicts conditioned pain modulation in adolescents across weight status
Author(s) -
Stolzman S.,
Hoeger Bement M.
Publication year - 2016
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1002/ejp.821
Subject(s) - overweight , anthropometry , medicine , lean body mass , physical therapy , body mass index , body weight
Background There is a wide continuum of conditioned pain modulation ( CPM ) in adults with older adults experiencing an attenuated CPM response compared with younger adults. Less is known for adolescents and the role of anthropometrics. Methods Fifty‐six adolescents (15.1 ± 1.8 years; 32 normal weight and 24 overweight/obese; 27 boys) completed in a CPM session that included anthropometric testing. Pressure pain thresholds were measured at the nailbed and deltoid muscle (test stimuli) with the foot submerged in a cool or ice water bath (conditioning stimulus). Weight status, body composition (Dual‐energy X‐ray absorptiometry scan), physical activity levels and clinical pain were also evaluated. Results The CPM response in adolescents was similar across sites (nailbed vs. deltoid), weight status (normal vs. overweight/obese) and sex. CPM measured at the deltoid muscle was positively associated with left arm lean mass but not fat mass; lean mass of the arm uniquely predicted 10% of the CPM magnitude. CPM measured at the nailbed was positively correlated with physical activity levels. Conclusions These results suggest that lean mass and physical activity levels may contribute to endogenous pain inhibition in adolescents across weight status.