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Whole‐body reversible neuropathic pain associated with right parieto‐temporal operculum single inflammatory lesion in a patient with multiple sclerosis: A case report
Author(s) -
PoncetMegemont Louis,
Dallel Radhouane,
Chassain Carine,
Perrey Antoine,
Mathais Sophie,
Clavelou Pierre,
Moisset Xavier
Publication year - 2019
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1002/ejp.1464
Subject(s) - lesion , neuropathic pain , medicine , diffusion mri , multiple sclerosis , neuroscience , complex regional pain syndrome , anesthesia , magnetic resonance imaging , psychology , radiology , pathology , psychiatry
Abstract Background The posterior insula and the medial parietal operculum (PIMO) are part of the pain network. Pain can be induced by direct stimulation of the PIMO, but the clinical consequence of lesions in this brain area is not well known. Case report We report the case of a patient with multiple sclerosis who presented a relapse characterized by isolated widespread neuropathic pain. The MRI displayed a single new inflammatory lesion in the juxta cortical white matter of the opercular region. This lesion was extended to the parietal operculum and was associated with the pain syndrome. The patient was treated with high‐dose intravenous methylprednisolone, and the pain disappeared progressively. Diffusion‐tensor MRI showed that some of the fibres passing through the lesion ended in the PIMO. Conclusion Based on diffusion‐tensor MRI we hypothesize that the partial disconnection from afference to the PIMO can lead to widespread neuropathic pain. Significance Most of the data concerning the functional role of the PIMO come from stereoelectroencephalography in presurgical evaluation of epilepsy, or from functional imaging (PET or fMRI). There is, however, very few data on the consequences of the lesion of the PIMO. Here, we report the first case of a transient widespread pain syndrome associated to a single, small and reversible inflammatory lesion of the PIMO. Thus, this case highlights the key role of the PIMO in spatial perception of pain.