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Cover Feature: Donor‐Reactivity‐Controlled Sialylation Reactions (Eur. J. Org. Chem. 32/2021)
Author(s) -
Haile Asressu Kesatebrhan,
Chang ChunWei,
Lam Sarah,
Wang ChengChung
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100952
Subject(s) - chemistry , reactivity (psychology) , cover (algebra) , stereoselectivity , turn (biochemistry) , feature (linguistics) , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , engineering , medicine , mechanical engineering , linguistics , alternative medicine , philosophy , pathology , biochemistry
The Cover Feature shows that the Relative Reactivity Value (RRV) is an effective stereoselectivity navigator for a sialylation reaction under the NIS/TfOH promotion system for the driver (chemist). The right turn and left turn signals are symbolizing the α ‐ and β ‐sialosides, respectively, using donor RRV as a direction indicator. Thiosialoside donors having RRV <11.5 enable selective synthesis of α ‐sialosides (right turn signal). On the other hand, donors with RRV ≥11.5 perform β ‐selective sialylation reactions (left turn signal). The authors thank Ms. Chiu‐Yun Chen in our Institute for her assistance in creating the artwork. More information can be found in the Full Paper by C.‐C. Wang et al.