Continuous Flow Organocatalytic Chlorination of Alkenes | Zendy

Iordanidis Nicolaos S. | Zendy; Zografos Alexandros L. | Zendy; Gallos John K. | Zendy; Koftis Theocharis V. | Zendy; Stathakis Christos I. | Zendy

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Continuous Flow Organocatalytic Chlorination of Alkenes

Author(s) -

Iordanidis Nicolaos S.,

Zografos Alexandros L.,

Gallos John K.,

Koftis Theocharis V.,

Stathakis Christos I.

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202100912

Subject(s) - chemistry , stoichiometry , allylic rearrangement , sulfoxide , continuous flow , regioselectivity , catalysis , environmentally friendly , combinatorial chemistry , organic chemistry , biochemical engineering , ecology , biology , engineering

A regioselective anti ‐dichlorination and allylic chlorination of isolated double bonds is described. Such chlorination reactions benefit from a combination of methyl phenyl sulfoxide and TMSCl. The method has been appropriately adjusted to fit the continuous flow technology requirements, aiming to a broader industrial implementation for the synthesis of pharmaceutically important compounds. Towards the same direction, a catalytic protocol has been developed, using sub‐stoichiometric amount of sulfoxide and environmentally friendly H 2 O 2 as the stoichiometric oxidant, with comparable efficacy.

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