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Front Cover: Pd 0 ‐Mediated Cross‐Coupling of [ 11 C]Methyl Iodide with Carboxysilane for Synthesis of [ 11 C]Acetic Acid and its Active Esters: 11 C‐Acetylation of Small, Medium, and Large Molecules (Eur. J. Org. Chem. 29/2021)
Author(s) -
Doi Hisashi,
Goto Miki,
Sato Yuzuru
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100876
Subject(s) - chemistry , front cover , methyl iodide , molecule , acetylation , acetic acid , iodide , reagent , stereochemistry , radiochemistry , organic chemistry , cover (algebra) , mechanical engineering , biochemistry , engineering , gene
The Front Cover shows a demonstration of 11 C‐acetylation radiolabeling of small, medium, and large molecules. A rapid Pd 0 ‐mediated cross‐coupling of radioactive [ 11 C]methyl iodide and carboxytriphenylsilane was developed for synthesis of [2‐ 11 C]acetic acid and its active esters as 11 C‐acetylation reagents. The 11 C‐acetylated molecules can be used for in vivo PET imaging in the field of life science. More information can be found in the Full Paper by H. Doi et al.