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An Efficient Construction of CF 3 ‐Substituted Spirooxindole‐Fused Benzo[a]quinolizidines by a Three‐Component Cyclization
Author(s) -
Hu Yijie,
Ye Liufeiyang,
Chen Jie,
Zhang Hui,
Deng Hongmei,
Lin JinHong,
Cao Weiguo
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100809
Subject(s) - quinolizidine , chemistry , component (thermodynamics) , block (permutation group theory) , stereochemistry , combinatorial chemistry , organic chemistry , alkaloid , mathematics , combinatorics , physics , thermodynamics
Benzo[a]quinolizidine is a key subunit in numerous natural products and pharmaceuticals, and therefore its synthesis has received much attention in resent years. Described herein is a convenient three‐component cyclization for the efficient construction of CF 3 ‐substituted spirooxindole‐fused benzo[a]quinolizidines by using CF 3 ‐propiolate as a building block. This attractive protocol may find great synthetic utility since CF 3 ‐containing complex structures were installed by a one‐step cyclization under mild conditions.