An Efficient Construction of CF 3 ‐Substituted Spirooxindole‐Fused Benzo[a]quinolizidines by a Three‐Component Cyclization | Zendy

Hu Yijie | Zendy; Ye Liufeiyang | Zendy; Chen Jie | Zendy; Zhang Hui | Zendy; Deng Hongmei | Zendy; Lin JinHong | Zendy; Cao Weiguo | Zendy

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An Efficient Construction of CF 3 ‐Substituted Spirooxindole‐Fused Benzo[a]quinolizidines by a Three‐Component Cyclization

Author(s) -

Hu Yijie,

Ye Liufeiyang,

Chen Jie,

Zhang Hui,

Deng Hongmei,

Lin JinHong,

Cao Weiguo

Publication year - 2021

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202100809

Subject(s) - quinolizidine , chemistry , component (thermodynamics) , block (permutation group theory) , stereochemistry , combinatorial chemistry , organic chemistry , alkaloid , mathematics , combinatorics , physics , thermodynamics

Benzo[a]quinolizidine is a key subunit in numerous natural products and pharmaceuticals, and therefore its synthesis has received much attention in resent years. Described herein is a convenient three‐component cyclization for the efficient construction of CF 3 ‐substituted spirooxindole‐fused benzo[a]quinolizidines by using CF 3 ‐propiolate as a building block. This attractive protocol may find great synthetic utility since CF 3 ‐containing complex structures were installed by a one‐step cyclization under mild conditions.

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