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S,O‐Ligand‐Promoted Pd‐Catalyzed C−H Olefination of Anisole Derivatives
Author(s) -
Sukowski Verena,
Jia WenLiang,
Diest Rianne,
Borselen Manuela,
FernándezIbáñez M. Ángeles
Publication year - 2021
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202100737
Subject(s) - anisole , chemistry , aryl , catalysis , reagent , ligand (biochemistry) , medicinal chemistry , organic chemistry , combinatorial chemistry , receptor , biochemistry , alkyl
The C−H olefination of substituted anisole derivatives by a Pd/S,O‐ligand catalyst is reported. The reaction proceeds under mild conditions with a broad range of substituted aryl ethers bearing both electron donating and withdrawing substituents at ortho , meta and para positions. Aryl ethers are used as limiting reagents and good yields and site selectivities are observed. The methodology is operationally simple and can be performed under aerobic conditions.